This discussion addresses the strengths and weaknesses of epidemiological research considering case studies of suicide and antidepressants among youth. In an epidemiological study of suicide-related events in young people following antidepressant prescriptions, Wijlaars et al (2013) examined the temporal association between selective serotonin reuptake inhibitors (SSRIs), tricyclic antidepressant (TCA) prescriptions and events related to suicide in children and adolescents. Electronic medical records from 479 general practices and the UK primary care database from 1995 to 2009 were used. Registers and epidemiological research on the young population indicated that 81 young people committed suicide and 1,496 attempted suicide, with 1,178 cases of suicidal ideation and 2,361 cases. of intentional self-harm. Incidence rate ratios (IRRs) were obtained for completed and attempted suicide, suicidal ideation, and intentional self-harm. Studies have indicated that for nonfatal suicide-related behavior, IRRs tend to increase during pre-exposure and peak during prescription periods and decline after stopping prescribing medications. Epidemiological research has indicated that there is an increase in the IRR for completed suicide during the day of prescription and during the fourth week of prescription. The study by Wijlaars et al (2013) found that a number of young people who were prescribed antidepressants showed no increased incidence or rates of suicide, suicidal ideation or intentional self-harm. The researchers recommended active pharmacovigilance to prevent antidepressant-related suicide by monitoring antidepressant intake and the prescription period such as the day of prescription and the fourth week after prescription with...... half of the paper... ...cides and antidepressants cannot necessarily prevent suicide. Antidepressant use sometimes increases the risk of suicide among young adults, and epidemiological studies have proven inconclusive. The study by Wijlaars et al (2013) demonstrated that young people taking antidepressants do not necessarily have increased rates of self-harm or suicidal risk. Filakovic and Eric (2013) instead highlighted the limited role of antidepressants in preventing suicidal behavior among mentally ill young adults. Sanchez-Gistau et al (2013) suggested that antidepressant treatment was associated with a high risk of suicide. Studies and epidemiological study results may vary significantly, and there is no conclusive argument on the definitive correlation between antidepressant use and increased or decreased suicidal behavior among youth.