Throughout the eight series of House MD, Dr. Gregory House's unique work style is what creates the unique interpersonal relationships that critics and audiences have been talking about. Each episode featured a certain amount of conflict, whether it was with his boss, best friend, or a patient. Although House is typically known for a narcissistic and self-obsessed personality throughout the series, he manages to maintain a number of key relationships with his boss and best friend. House's most important interpersonal relationship throughout the series is with his boss, Dr. Lisa Cuddy. . When the series begins, the viewer learns that she had to make a critical decision on House's behalf after he fell into a coma due to severe muscle damage in his leg. Cuddy's decision to take House's side and remove the dead muscle instead of amputating his leg is the root of their relationship. House interacts with Cuddy primarily through conflicts at the hospital. During a diagnosis, House commonly uses an unorthodox and extremely risky procedure on his patients. These procedures require Cuddy's permission to b...