Topic > Mesenchymal stem cells and their use in treatment

Mesenchymal stem cells by definition can be described as multipotent progenitors, self-renewing cells with multiple pathways having the potential to differentiate into cell types of mesodermal origin such as osteocytes, adipocytes and chondrocytes. We say no to plagiarism. Get a tailor-made essay on "Why Violent Video Games Shouldn't Be Banned"? Get an original essay They are usually isolated from bone marrow and in some cases also isolated from other tissues such as placenta, adipose tissue, amniotic fluid and umbilical cord blood. For all types of cell therapy mesenchymal stem cells have been considered the gold standard as they are readily available and also due to the fact that they can be easily expanded. The unique feature of their multipotency has been used in tissue repair and regenerative medicine. Their therapeutic potential is also enormous since the secretion of their soluble factors can be used to induce an immunomodulatory environment. There is enormous interest in the application of mesenchymal stem cells and it has become the stem cell of choice for regenerative drugs, one reason is partly due to the ease with which it can be isolated from tissues and the way it works in a wide range of diseases. Mesenchymal stem cells have been used in the treatment of bone disorders, such as osteogenesis imperfecta and hypophosphatasia. Patients in the pediatric age group undergo allogeneic hematopoietic stem cell transplantation. Subsequently the transplanted bone marrow cells are engrafted and generated as functional osteoblasts leading to normal bone growth progenesis. It is also successfully used in the treatment of cardiovascular diseases. Thanks to its regenerative and immunomodulatory properties it is considered an ideal candidate for the repair and regeneration of cardiovascular tissues. Thanks to the modulation properties of immune responses by mesenchymal stem cells, it is also very effective in the treatment of autoimmune diseases. Thanks to its regenerative capacity it is also very effective in the treatment of liver diseases such as liver cirrhosis. Mesenchymal stem cells are genetically modified to express various anticancer genes. Mesenchymal stem cells play a significant role in creating innovative therapeutic protocols for diseases for which there is currently no effective real-time treatment with all modern conveniences. It has made breakthroughs in graft-versus-host disease and cardiovascular disease because of the complexities associated with these disorders. The specific role of mesenchymal stem cells has yet to be ascertained by completing clinical trials in myocardial infarction, stroke, liver cirrhosis, amyotrophic lateral sclerosis, and graft-versus-host disease. The main routes for the therapeutic mechanisms of mesenchymal stem cells are: -ImmunomodulationNeuroprotectionNeurogenerationRegenerative approaches based on mesenchymal stem cells are increasingly required especially in musculoskeletal disorders. It is a matter of time when therapies for non-fatal diseases will begin to show better results than standard treatment protocols. These MSCs will be able to demonstrate long-term cost-effectiveness and name in the therapeutic regimen of all standard protocols. One area of ​​particular interest that concerned me was cardiovascular diseases as they are commonly encountered and again difficult to treat sometimes even with maximum effort in the most.